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A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis

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Title A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis
 
Creator Verma, Deepanjali
Jalmi, Siddhi Kashinath
Bhagat, Prakash Kumar
Verma, Neetu
Sinha, Alok Krishna
 
Subject MAP Kinase
MPK6
MYC2
P5CS1
Proline
Salinity
Seed germination
Root growth
 
Description Accepted date: 26 Nov 2019
MYC2, a bHLH TF, acts as regulatory hub within several signaling pathways by integration of various endogenous and exogenous signals which shape plant growth and development. However, its involvement in salt stress regulation is still elusive. This study has deciphered a novel role of MYC2 in imparting salt stress intolerance by regulating P5CS1 gene and hence proline synthesis. P5CS1 is a rate limiting enzyme in the biosynthesis of proline. Y‐1‐H and EMSA studies confirmed the binding of MYC2 with the 5’ UTR region of P5CS1. Transcript and biochemical studies have revealed MYC2 as a negative regulator of proline biosynthesis. Proline is necessary for imparting tolerance towards abiotic stress however, its overaccumulation is toxic for the plants. Hence studying the regulation of proline biosynthesis is requisite to understand the mechanism of stress tolerance. We have also studied that MYC2 is regulated by MAPK cascade MKK3‐MPK6 and vice versa. Altogether, this study demonstrates salt stress mediated activation of MYC2 by MAPK cascade, regulating proline biosynthesis and thus salt stress.
 
Date 2019-12-12T09:54:33Z
2019-12-12T09:54:33Z
2020
 
Type Article
 
Identifier FEBS Journal, (In Press)
1742-4658
http://223.31.159.10:8080/jspui/handle/123456789/1019
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15157
https://doi.org/10.1111/febs.15157
 
Language en_US
 
Format application/pdf
 
Publisher John Wiley & Sons