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Alternative oxidase is an important player in the regulation of nitric oxide levels under normoxic and hypoxic conditions in plants

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Title Alternative oxidase is an important player in the regulation of nitric oxide levels under normoxic and hypoxic conditions in plants
 
Creator Kumari, Aprajita
Pathak, Pradeep Kumar
Bulle, Mallesham
Igamberdiev, Abir U
Gupta, Kapuganti Jagadis
 
Subject alternative oxidase
nitric oxide
nitrite
cytochrome c oxidase
phytoglobin
nitrate reductase
 
Description Accepted date: 10 April 2019
Plant mitochondria possess two different pathways for electron transport from ubiquinol: the cytochrome pathway and the alternative oxidase (AOX) pathway. The AOX pathway plays an important role in stress tolerance and is induced by various metabolites and signals. Previously, several lines of evidence suggested that the AOX pathway prevents overproduction of superoxide and other reactive oxygen species. More recent evidence suggests that AOX also plays a role in regulation of nitric oxide (NO) production and signalling. The AOX pathway is induced under low phosphate, hypoxia, pathogen infections and elicitor treatments. The induction of AOX under aerobic conditions in response to various stresses can reduce electron transfer through complexes III and IV and thus prevents the leakage of electrons to nitrite and the subsequent accumulation of NO. Excess of NO under various stresses can inhibit complex IV, thus the AOX pathway minimizes nitrite-dependent NO synthesis that would arise from enhanced electron leakage in the cytochrome pathway. By preventing NO generation, AOX can reduce peroxynitrite formation and tyrosine nitration. In contrast to its function under normoxia, AOX has a specific role under hypoxia, where AOX can facilitate nitrite-dependent NO production. This reaction drives the phytoglobin-NO cycle to increase energy efficiency under hypoxia.
The work in KJG lab is supported by Ramalingaswami
Fellowship, IYBA and Research grant (BT/PR23711/BPA118/343/2017) from
Department of Biotechnology, Government of India. PKP is supported by SRF
fellowship from UGC, India.
 
Date 2019-04-18T09:58:35Z
2019-04-18T09:58:35Z
2019
 
Type Article
 
Identifier Journal of Experimental Botany, 70(17): 4345-4354
1460-2431
http://223.31.159.10:8080/jspui/handle/123456789/942
https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/erz160/5436428
https://doi.org/10.1093/jxb/erz160
 
Language en_US
 
Format application/pdf
 
Publisher Oxford University Press