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Genome-wide association study (GWAS) delineates genomic loci for ten nutritional elements in foxtail millet (Setaria italica L.)

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Title Genome-wide association study (GWAS) delineates genomic loci for ten nutritional elements in foxtail millet (Setaria italica L.)
 
Creator Jaiswal, Vandana
Bandyopadhyay, Tirthankar
Gahlaut, Vijay
Gupta, Sarika
Dhaka, Annvi
Ramchiary, Nirala
Prasad, Manoj
 
Subject Foxtail millet
Genome-wide association study
Nutritional elements
Single nucleotide polymorphism
 
Description Accepted date: 18 November 2018
Nutritional deficiency is found to be a major threat to human health, especially in low-income countries. Thus it is essential to improve nutritional qualities of important food crops. Foxtail millet is second largest cultivated millet and 2–5 times nutritionally richer than major cereal crops. During the present study, we identified genetic determinants of ten nutritional elements including potassium, nickel, calcium, boron, magnesium, phosphorus, sulphur, zinc, manganese and iron for the first time in foxtail millet. For this purpose, genome-wide association studies (GWAS) were conducted using 93 diverse accessions and 10 K SNPs (distributed across all the nine foxtail millet chromosomes). Altogether, 74 marker-trait associations (MTAs) were identified to be associated with above mentioned ten elements, out of which ten (10) MTAs (associated with B, Mg, Zn and Fe) showed high confidence [-log(p) > 5.78]. Identified desirable SNP alleles and favourable haplotypes may prove useful in foxtail breeding. Also, significant pyramiding effect suggested that associated elements can be substantially enhanced through combining more than one MTA. Candidate genes residing within or near the association signal may be selected for functional characterization. Superior genotypes identified may prove as a potential donor in foxtail millet breeding assisted through the molecular marker.
The work was supported by the Department of Biotechnology
(DBT), Ministry of Science and Technology, Government of India [BT/
HRD/NBA/37/01/2014(vii)]. MP acknowledges the financial support received through National
Bioscience Award (2015) from Department of Biotechnology (DBT),
Ministry of Science and Technology, Government of India. VJ and VG
acknowledge the DST-INSPIRE Faculty Awards received from
Department of Science and Technology, Ministry of Science and
Technology, Government of India. AD acknowledges University Grants Commission, Government of India, for providing research fellowship.
The authors are thankful to DBT-eLibrary Consortium (DeLCON) for
providing access to e-resources.
 
Date 2019-01-15T07:37:25Z
2019-01-15T07:37:25Z
2019
 
Type Article
 
Identifier Journal of Cereal Science, 85: 48-55
0733-5210
http://223.31.159.10:8080/jspui/handle/123456789/912
https://www.sciencedirect.com/science/article/pii/S0733521018307173
https://doi.org/10.1016/j.jcs.2018.11.006
 
Language en_US
 
Format application/pdf
 
Publisher Elsevier B.V.