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Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during Fusarium infection of Caenorhabditis elegans

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Title Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during Fusarium infection of Caenorhabditis elegans
 
Creator Nag, Papri
Aggarwal, Pooja Rani
Ghosh, Sudip
Narula, Kanika
Tayal, Rajul
Maheshwari, Nidhi
Chakraborty, Niranjan
Chakraborty, Subhra
 
Subject Fungal infection
Transcriptomics
Fusarium
Caenorhabditis elegans
neuronal and non-neuronal genes
DAF-16-mediated immune
 
Description Accepted date: 13 September 2017
Although precisely controlled innate immune response is governed by conserved cellular events in phylogenetically diverse hosts, the underlying molecular mechanisms by which this process is regulated against a multi-host pathogen remain unknown. Fusarium oxysporum is a model multi-host pathogen, known to be associated with neuronal stress in humans and vascular wilt in plants. The interaction between innate immune and neuronal pathways is the basis of many diverse biological responses. How these processes are coordinated in response to fungal disease is not well understood. Here, we show that F. oxysporum f. sp. ciceri causes neuronal stress and intestinal disintegration, ultimately leading to the death of Caenorhabditis elegans. To explore the regulatory framework of Fusarium-associated disease, we analysed the gene expression during infection, integrated temporal gene expression, and network analysis with genetic inactivation data in Caenorhabditis elegans. We identified 1024 genes showing significant changes in expression (corrected P-values
This work was supported by grants from the Department of Biotechnology (DBT)
(BT/HRD/35/01/05/2013), Government of India and the National Institute of Plant
Genome Research, New Delhi, India to SC. PA is the recipient of pre-doctoral
fellowship from the Council of Scientific and Industrial Research (CSIR), Govt. of India.
KN is the recipient of postdoctoral fellowship from the Department of Biotechnology
(DBT), Govt. of India. We thank the Caenorhabditis Genetics Centre (Univ. of
Minnesota) for strains used in this study. We also thank Mr Jasbeer Singh for
illustrations and graphical representations in the manuscript.
 
Date 2017-11-22T06:01:52Z
2017-11-22T06:01:52Z
2017
 
Type Article
 
Identifier Cell Death Discovery, 3: 17073
2058-7716
http://223.31.159.10:8080/jspui/handle/123456789/802
https://www.nature.com/articles/cddiscovery201773
10.1038/cddiscovery.2017.73
 
Language en_US
 
Format application/pdf
 
Publisher Nature Publishing Group