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Burkholderia gladioli strain NGJ1 deploys a prophage tail-like protein for mycophagy

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Title Burkholderia gladioli strain NGJ1 deploys a prophage tail-like protein for mycophagy
 
Creator Kumar, Rahul
Yadav, Sunil Kumar
Swain, Durga Madhab
Jha, Gopaljee
 
Subject bacterial mycophagy
phage tail protein
sheath blight disease
Fungal diseases
rice
microbiome
anti-fungal compound
biocontrol
 
Description Accepted date: 19/Dec/2017
Fungal pathogens are responsible for approximately
two third of the infectious plant diseases. Historically
they have been associated with several devastating
famines, causing death and disabilities in humans.
Mostly fungal diseases are being controlled by using
fungicides which otherwise have adverse side effects
on the health of consumers as well as environment.
Due to extensive usages, pathogens have evolved resistance
against most of the commonly used fungicides
and rendered them ineffective. Controlling fungal disease
in a sustainable and eco-friendly fashion remains
a challenge. The antifungal biocontrol agents are being
considered as potent, alternative and ecofriendly approach
to manage fungal diseases. In our recent work,
we have identified a rice associated bacterium;
Burkholderia gladioli strain NGJ1 which demonstrates
broad spectrum fungal eating (mycophagous) property.
We determined that the bacterium utilizes its type III
secretion system (Injectisome) machinery to deploy a
prophage tail-like protein (Bg_9562) into fungal cells to
devour them. The purified Bg_9562 protein from overexpressing
recombinant E. coli strain demonstrates
broad spectrum antifungal activity. Overall our study
opens up a new opportunity to exploit prophage taillike
protein as potent antifungal compound to control
plant as well as animal fungal diseases.
The research funding from DBT, Gov-ernment of India and core research grant of National Institute of Plant Genome Research, to support GJ lab is gratefully acknowledged. RK acknowledge fellowship from CSIR and SKY acknowledges fellowship from DBT.
 
Date 2018-02-06T06:33:42Z
2018-02-06T06:33:42Z
2018
 
Type Article
 
Identifier Microbial Cell 5(2): 116 – 118
2311-2638
http://223.31.159.10:8080/jspui/handle/123456789/833
http://microbialcell.com/researcharticles/burkholderia-gladioli-strain-ngj1-deploys-a-prophage-tail-like-protein-for-mycophagy/
10.15698/mic2018.02.617
 
Language en_US
 
Format application/pdf
 
Publisher Shared Science Publishers OG