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Integrated genomic strategies for cereal genetic enhancement: combining QTL and association mapping

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Title Integrated genomic strategies for cereal genetic enhancement: combining QTL and association mapping
 
Creator Daware, Anurag
Parida, Swarup K.
Tyagi, Akhilesh K.
 
Subject Association mapping
Fine mapping
Linkage mapping
MetaQTL
QTL
 
Description Accepted date: 21 September 2019
Identification of genetic basis for important agronomic traits is essential for marker-assisted crop improvement. Linkage mapping is one of the most popular approaches utilized for identification of major quantitative trait loci (QTLs) governing important agronomic traits in cereals. However, the identified QTLs usually span large genomic intervals and very few of these are subsequently fine mapped to single major effect gene. This hinders application of these QTLs in marker-aided breeding and crop genetic enhancement. On the contrary, association mapping, another popular approach for identification of QTLs, provides very high resolution but suffers from high level of false positives. Joint linkage-association analysis provides a way to combine advantages and avoid the pitfalls associated with both these methods. In this context, we recently developed MetaQTL specific regional association analysis and demonstrated its utility to rapidly narrow down previously identified QTL intervals to few candidate genes. Here, we describe the detailed step-by-step guide for performing MetaQTL specific regional association analysis to identify important genomic regions and underlying potential major effect genes governing traits of agronomic importance in cereals.
The work in lab is supported by grants from DBT and SERB, Government of India.
 
Date 2019-09-23T10:28:57Z
2019-09-23T10:28:57Z
2020
 
Type Article
 
Identifier Methods in Molecular Biology, 2072: 15-25
978-1-4939-9865-4
http://223.31.159.10:8080/jspui/handle/123456789/987
https://link.springer.com/protocol/10.1007%2F978-1-4939-9865-4_3
https://doi.org/10.1007/978-1-4939-9865-4_3
 
Language en_US
 
Format application/pdf
 
Publisher Springer Nature Publishing AG