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Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance.
 
Creator Srinivasan, Vijaya Bharathi
Rajamohan, Govindan
 
Subject QR Microbiology
 
Description In this study, we present the genome sequence of Serratia marcescens SM03, recovered from a human gut in India. The final assembly consists of 26 scaffolds (4620 coding DNA sequences, 5.08 Mb, 59.6% G + C ratio) and 79 tRNA genes. Analysis identified novel genes associated with lactose utilization, virulence, P-loop GTPases involved in urease production, CFA/I fimbriae apparatus and Yersinia - type CRISPR proteins. Antibiotic susceptibility testing indicated drug tolerant phenotype and inhibition assays demonstrated involvement of extrusion in resistance. Presence of enzymes SRT-2, AAC(6')-Ic, with additional Ybh transporter and EamA-like efflux pumps signifies the genetic plasticity observed in S. marcescens SM03.
 
Publisher Elsevier Science
 
Date 2019-07-01
 
Type Article
PeerReviewed
 
Identifier Srinivasan, Vijaya Bharathi and Rajamohan, Govindan (2019) Genome analysis of urease positive Serratia marcescens, co-producing SRT-2 and AAC(6')-Ic with multidrug efflux pumps for antimicrobial resistance. Genomics, 111 (4). pp. 653-660. ISSN 1089-8646
 
Relation http://crdd.osdd.net/open/2523/