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Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones

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Title Statement Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones
 
Added Entry - Uncontrolled Name Rajanarendar, E ; Department of Chemistry, Kakatiya University, Warangal 506 009, (T. S.), India
Sanjeev, Rella ; Department of Chemistry, Kakatiya University, Warangal 506 009, (T. S.), India
Thirupathaiah, Kammari ; Department of Chemistry, Kakatiya University, Warangal 506 009, (T. S.), India
 
Uncontrolled Index Term Isoxazolyl thiazolyl benzimidazoles, cyclocondensation, anti-inflammatory activity, analgesic activity 
 
Summary, etc. A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity.
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-02-11 16:52:26
 
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http://op.niscair.res.in/index.php/IJCB/article/view/27993
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 2 (2020): Indian Journal of Chemistry -Section B
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/27993/465486417
http://op.niscair.res.in/index.php/IJCB/article/download/27993/465486735
 
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