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<p>Synthesis, characterization, molecular docking studies and biological activity ofcoumarin linked 2-pyridone heterocycles</p>

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Title Statement <p>Synthesis, characterization, molecular docking studies and biological activity ofcoumarin linked 2-pyridone heterocycles</p>
 
Added Entry - Uncontrolled Name Desai, Nisheeth C; Maharaja Krishnakumarsinhji Bhavnagar University
Karkar, Tushar J; C B Patel Computer College and JNM Patel Science College (DRB), New Citylight Road, Bharthana (Vesu), Surat-395007, India
Vekariya, Rajesh H; Research Scientist, Piramal Pharma Solutions, Plot No.-18, Pharmez, Matoda Village, Ahmedabad, India
Joshi, Surbhi B; Maharaja Krishnakumarsinhji Bhavnagar University
Jadeja, Krunalsinh A; Maharaja Krishnakumarsinhji Bhavnagar University
Vaja, Darshita V; Maharaja Krishnakumarsinhji Bhavnagar University
Authors are thankful to the University Grants Commission, New Delhi and Department of Science & Technology, New Delhi for financial support under the NON-SAP and DST-FIST programs respectively. Mr. Krunalsinh A Jadeja is thankful to UGC, New Delhi for UGC
 
Uncontrolled Index Term Medicinal chemistry, antibacterial, antifungal, cytotoxicity, molecular docking
 
Summary, etc. <p style="text-align: justify;">In the present paper, the synthesis, characterization, antimicrobial activity and in silico molecular docking study of6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structuredetermination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed thatbiological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para positionplays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at paraposition for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From thecytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-02-11 16:52:26
 
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http://op.niscair.res.in/index.php/IJCB/article/view/27837
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 2 (2020): Indian Journal of Chemistry -Section B
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/27837/465485921
http://op.niscair.res.in/index.php/IJCB/article/download/27837/465486534
 
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