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<p style="text-align: justify;">Study of the safety profile of raw (<em>aśodhita)</em> and cow’s urine processed (<em>gomūtra śodhita) </em>tubers of <em>Gloriosa superba</em> L. (<em>Lāngali</em>) in albino rats<strong><br /></strong><strong></strong></p>

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Title Statement <p style="text-align: justify;">Study of the safety profile of raw (<em>aśodhita)</em> and cow’s urine processed (<em>gomūtra śodhita) </em>tubers of <em>Gloriosa superba</em> L. (<em>Lāngali</em>) in albino rats<strong><br /></strong><strong></strong></p>
 
Added Entry - Uncontrolled Name Bhide, Bhargav Vijay; Department of Dravyaguna, All India Institute of Ayurveda, Gautampuri, Sarita Vihar, Mathura Road New Delhi 110076, India
Acharya, Rabinarayan ; IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat
Ravishankar, B ; Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi 574118, Karnataka, India
Kolhe, Rasika ; Regional Ayurveda Institute for Fundamental Research, Kothrud, Near Gandhi Bhawan, Pune 411038, Maharashtra, India
Nariya, Mukesh ; Gujarat Ayurved University, Jamnagar 361008, Gujarat, India
 
Uncontrolled Index Term Pharmacological study
Gloriosa superba L.; Gomūtra, Lāngali; Sodhana, Toxicity; Upaviṣa.
 
Summary, etc. <p style="text-align: justify;"><em>Lāngali</em> (<em>Gloriosa superba</em> L.) is a drug in <em>upaviṣa varga</em> (semi-poisonous drug) which has to undergo <em>ś</em><em>odhana</em> procedure before its therapeutic use. The present study was planned to assess the role of <em>śodhana </em>of <em>Lāngali</em> tuber by <em>gomūtra </em>on its safety aspects in experimental animals, which is recommended by Ayurvedic Formulary of India. The therapeutic dose of <em>Lāngali</em> as per API is 125 to 250 mg/day. For the present study the higher dose i.e. 250 mg was selected. Wistar strain albino rats were used for the study. The animals were divided into seven groups and each group contained 12 animals (six male and six female). The study was done for 90 days followed by 30 days (total 120 days) recovery study. Various haematological, biochemical parameters and histopathology of the organs were studied. The study showed that <em>śodhana</em> process attenuates the toxicity producing potential of raw <em>L</em><em>ā</em><em>ngali. </em>When processed with <em>gomūtra</em>, <em>l</em><em>ā</em><em>ngali</em> root produces good spermatogenic effect while raw/ <em>aśodhita lāngali</em> hampers spermatogenesis at 10 times dose level. So it can be concluded that both raw and <em>śodhita</em> Langali found relatively safe up to 5 times therapeutic dose level.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-02-14 12:30:35
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/23901
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 3 (2019): September 2019
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/23901/465474745
http://op.niscair.res.in/index.php/IJNPR/article/download/23901/465474771
http://op.niscair.res.in/index.php/IJNPR/article/download/23901/465474772
http://op.niscair.res.in/index.php/IJNPR/article/download/23901/465474773
 
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