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| Field | Value |
| Title | Protective effect of squalene isoproterenol-induced myocardial infarction in rats |
| Names |
Farvin, K.H.S.
Anandan, R. Sankar, T.V. Nair, P.G.V. |
| Date Issued | 2005 (iso8601) |
| Abstract | The protective effect of squalane on membrane function and mineral status was examined in isoproterenol-induced myocardial infraction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the level of plasma diagnostic marker enzymes (ALS,AST,LDH and CPK), It countreacted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy.Supplimentation squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infraction by maintainig the activities of membrane-bound ATPases.in the heart tissue and the mineral status in plasma and heart tissue at near normal levels. The cardioprotective effect of squalane might be ascribable to its antioxidant nature and mambrane stabilizing properly. |
| Genre | Article |
| Topic | squalene |
| Identifier | Journal of Clinical Biochemical Nutrition 2005:37(2), 55-60 |