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Title Effect of red mangrove (rhizophora apiculata) root extract on sodium nitrite-induced oxidative stress in rats
 
Names Asha, K.K.
Mathew, S.
Remyakumari, K.R.
Date Issued 2010 (iso8601)
Abstract Oxidative stress arising from an imbalance in the antioxidant system
is responsible for the ailments of the heart, brain dysfunction, immune
system decline and also for aging. Thus there has been an increasing
interest in recent years in healthy life styles and interest in antioxidants
and food supplements has grown remarkably. The role of natural products
as a source for remedies has been recognized since ancient times (de
Pasquale, 1984). An analysis of a number of chemotherapeutic agents
and their sources indicates that over 60% of approved drugs are derived
from natural compounds (Cragg et at., 1997). With a proven record of
natural products in drug discovery, there is a compelling need for
expanding exploration of nature as a source of novel healing agents.
Besides the endogenous antioxidant defenses that combat the oxidative
stress, consumption of antioxidants appears to be important. Antioxidants
can be either synthetic or of natural origin. The use of synthetic
antioxidants in food is being discouraged by many health regulating
agencies in recent times. Plants are good sources of natural antioxidants
(Shahidi, 2000), which has been the basis of numerous studies in the
last decade. Among these, flavonoids and related phenolics have gained
importance. Unpublished data on mangrove plant, Rhizophora apiculata
or red mangrove, from GIFT, Cochin and earlier studies have established
that the root of this plant is a rich source of flavonoids and has several
low molecular weight compounds like glucosides, fatty acids, sterols and
hydrocarbons (Sharaf et at., 2000). Perera et at. (2008) extracted
polyphenolic compounds and flavonoids from root and bark of RhIzophora
mangle, a species closely related to R. apiculata. Several investigators
have established that mangroves are also rich in polyphenols, among which flavonoids are a significant group (Kathiresan and Ravi, 1990; Ravi
and Kathiresan, 1990; Achmadi et al., 1994). The aim of the present study
was to examine the effect of the ethanolic root extract of the mangrove
plant Rhizophora apiculata on experimentally induced oxidative stress in
brain tissue of male albino rats.
Genre Article
Topic Rhizophora apiculata
Identifier Proceedings of the National Seminar on Conservation and Sustainability of Coastal Living Resources of India, 1-3 December 2009, Cochin, ed.by Meenakumari, B. et.al 715-723