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| Field | Value |
| Title | Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infraction in rats |
| Names |
Anandan, R.
Kumar, S.H.S. Ganesan, B. Mathew, S. Lakshmanan, P.T. |
| Date Issued | 2013 (iso8601) |
| Abstract | Myocardial infraction is a major public health concern and the leading cause of all over the world. A better understanding of the processes involved in myocardial infraction has stimulated the search for biomolecules, which could limit the myocardial injury. we determined the protective activity of L-glutamine on mitochondrial function in isoprenaline induced myocardial infraction in rats, an animal model of myocardial infraction in man. Oral pre-treatment with glutamine significanly inhibited the isoprenaline-induced changes in the levels of troponin T and homocysteine in the plasma. It conserved the activities of tricarboxylic acid cyle enzymes (isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase) and respiratiory marker enzyme (NADH dehydrogenase) and the level of myocardial ATP content at levels comparable to that of normal controls. its also attenuated isoprenaline-induced oxidative stress in rat mitochondria and cardioprotective effect of glutamine can be correlated directly with its ability to activate the energy status and antioxidant defence system. |
| Genre | Article |
| Topic | isoprenaline |
| Identifier | Egyptian Journal of Biology 2013: 15(1), 28-36 |