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An evaluation of liposome-based diagnostics of pulmonary and extrapulmonary tuberculosis.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title An evaluation of liposome-based diagnostics of pulmonary and extrapulmonary tuberculosis.
 
Creator Tandel, Nikunj
Joseph, Anish Z
Joshi, Aishwarya
Shrama, Priya
Mishra, Ravi Pn
Tyagi, Rajeev K
Bisen, Prakash S
 
Subject QR Microbiology
 
Description : Tuberculosis (TB) is still one of the major global health threats and delayed diagnosis or misdiagnosis continues to fuel the global epidemic. The conventional diagnostic approaches have shortcomings that might hinder the process of diagnosis of the disease and ultimately affect the prognosis.: We emphasize on the process of the synthesis of liposomes, its physicochemical properties affecting the formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, and specific, and most importantly, one that enables us to demarcate patients with active tuberculosis from those with quiescent lesions, prior vaccination, or other diseases.: The utility of liposomes for diagnostic purposes has been attempted so as to overcome the challenges posed by conventional diagnostic tools for Tuberculosis. Through this review we present insights into liposome formulation and selection processes, various studies that report the use of liposome-based diagnostic tools for tuberculosis, as well as the limitations associated with the same that can be improvised to make the technology more efficient.
 
Publisher Taylor & Francis
 
Date 2020-05-09
 
Type Article
PeerReviewed
 
Relation https://www.tandfonline.com/doi/abs/10.1080/14737159.2020.1740596?journalCode=iero20
http://crdd.osdd.net/open/2551/
 
Identifier Tandel, Nikunj and Joseph, Anish Z and Joshi, Aishwarya and Shrama, Priya and Mishra, Ravi Pn and Tyagi, Rajeev K and Bisen, Prakash S (2020) An evaluation of liposome-based diagnostics of pulmonary and extrapulmonary tuberculosis. Expert review of molecular diagnostics. pp. 20-5. ISSN 1744-8352