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| Field | Value |
| Title | Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus |
| Names |
Muthuchelvan, D.
Sanyal, A. Sreenivasa, B.P. Saravanan, P. Dhar, P. Singh, R.P. Bandyopadhyay, S.K. |
| Date Issued | 2006 (iso8601) |
| Abstract | The M gene nucleotide sequence of an Indian peste-des-petits ruminants (PPRV) vaccine virus (‘‘PPRV Sungri/96’’) belonging to Asian lineage was determined. The gene is 1476 nucleotides long with a single open reading frame (ORF). The nucleotide and predicted amino acid sequence was compared with the homologous region of the African Lineage Vaccine virus ‘‘PPRV/Nigeria/75/1’’. The nucleotide sequence of the ‘‘PPRV Sungri/96’’ was 86% identical to that of ‘‘PPRV/Nigeria/75/1’’, while a homology of 93% and 95% could be observed in the ORF and amino acids level, respectively. The M gene encodes a protein of 335 amino acids, with a predicted molecular weight (MW) of 37.8 kDa. The ORF is flanked by a 30 untranslated region of 436 nucleotides and a high level of sequence divergence ( 30%) could be observed in this region between the vaccine viruses of Asian and African lineages. A high degree of conservation of several amino acids of this protein observed previously was also confirmed in this study. |
| Genre | Article |
| Topic | Morbillivirus |
| Identifier | Veterinary Microbiology 2006: 113(1), 83-87 |