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Title Protective effect of betaine on changes in the levels of membrabe-bound ATPase activity and mineral status in experimentally induced myocardial infarction in wistar rats
 
Names Ganesan, B.
Buddan, S.
Jeyakumar, R.
Anandan, R.
Date Issued 2009 (iso8601)
Abstract Cardiovascular diseases are emerging as a major public health problem in most
parts of the world even in developing countries still afflicted by infectious diseases,
undernutrition, and other illnesses related to poverty. In the present study, we investigated
the protective effect of betaine, a potent lipotropic molecule, on changes in the levels of
membrane-bound ATPase activities, lipid peroxidation, sulfhydryl activities, and mineral
status in isoprenaline-induced myocardial infarction in Wistar rats, an animal model of
myocardial infarction in man. Oral administration of betaine (250 mg/kg body weight/day
for a period of 30 days) significantly (p<0.05) reduced the isoprenaline-induced
abnormalities noted in the levels of sodium, potassium, and calcium in plasma and heart
tissue. Pretreatment with betaine significantly attenuated isoprenaline-induced membrane-bound
ATPase depletion in the heart tissue and preserved the myocardial membrane-bound
ATPase activities at levels comparable to that of control rats. Oral administration of betaine
significantly attenuated the isoprenaline-altered sulfhydryl groups in the heart tissue and
preserved the myocardial sulfhydryl activities at levels comparable to that of control rats. It
also significantly counteracted the isoprenaline-mediated lipid peroxidation and maintained
the level at near normal. In the results of the present study, betaine administration
significantly prevented the isoprenaline-induced alterations in the activities of membrane-bound
ATPases, lipid peroxides, myocardial sulfhydryl levels, and maintained the mineral
status at near normal.
Genre Article
Identifier J. Biol. Trace Element. Res. 131(3):278-290