Record Details

<p style="text-align: justify;">Protective effect of ethanolic leaf extract of Alphonsea sclerocarpa against ethylene glycol induced urolithiasis in rats</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Protective effect of ethanolic leaf extract of Alphonsea sclerocarpa against ethylene glycol induced urolithiasis in rats</p>
 
Added Entry - Uncontrolled Name Chandrasekar, Raju ; Seven Hills COllege of Pharmacy, Jawaharlal Nehru Technological University, Ananthapuramu
Jayanth, P C ; Department of Pharmacology, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati, Chitoor District 517561, Andhra Pradesh, India
Babu, M Niranjan; Department of Pharmacognosy, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati, Chitoor District 517561, Andhra Pradesh, India
 
Uncontrolled Index Term Alphonsea sclerocarpa Thwaites; Antiurolithiatic activity, Ethylene glycol, Kidney stones.
 
Summary, etc. <p style="text-align: justify;"><em>Alphonsea sclerocarpa </em>Thwaites belonging to the family Annonaceae is a small tree, which grows up to 10-15 m tall the leaves are simple and alternate. Despite its medicinal properties the plant seems to be less explored and hence this research aims at exploring the antiurolithiatic activity of ethanolic leaf extract of <em>A. sclerocarpa </em>on ethylene glycol induced urolithiasis in rats. <em>A. sclerocarpa </em>leaf powder was extracted using ethanol. The effect of ethanolic leaf extract of <em>A. sclerocarpa </em>(250 and 500 mg/kg, p.o.) was studied in experimentally induced renal stone in rats by <em>in vivo </em>model. Ethylene glycol model (0.75% in drinking water, for 28 days) was used for renal stone induction. The blood, urine and kidney samples were used for various parameters. The concentration of calcium, oxalate, phosphorus, creatinine and blood urea nitrogen was observed in each group. The phytochemical analysis was carried out to detect the presence of secondary metabolites like saponins and flavonoids in the ethanolic extract of <em>A. sclerocarpa </em>leaf extract. In ethylene glycol (0.75% v/v) treated animal model ethanolic extract of <em>A. sclerocarpa </em>leaf extract showed significant results on stone promoters (calcium oxalate, inorganic phosphate and sodium), kidney function parameters (uric acid, blood urea nitrogen, creatinine). On the basis of biochemical parameters and histopathological study it was confirmed that <em>A. sclerocarpa </em>leaf extract protected the renal cells from oxidative stress and injury induce by calcium oxalate crystals. The investigation of ethanolic extract of <em>A. sclerocarpa </em>leaf has shown promising antiurolithiatic activity and support folklore claims of these plants as antiurolithiatic. The mechanism of action of these plants for antiurolithiatic is apparently related to increased diuresis and lowering of urinary concentrations of stone-forming constituents, though it should be confirmed by the extensive exploratory studies.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-05-08 21:02:28
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/24090
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 4 (2019): December 2019
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.