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<p style="text-align: justify;">DPP-IV Inhibitors from natural sources: An alternative approach for treatment and management of diabetes</p>

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Title Statement <p style="text-align: justify;">DPP-IV Inhibitors from natural sources: An alternative approach for treatment and management of diabetes</p>
 
Added Entry - Uncontrolled Name Sharma, Divya ; Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
Kumar, Sandeep ; Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
Kumar, Sunil ; Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
Kumar, Dinesh ; Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
 
Uncontrolled Index Term Active constituents; Diabetes; DPP-IV inhibitors; DPP-IV; GLP-1; Natural products.
 
Summary, etc. <p style="text-align: justify;">Diabetes is a chronic metabolic disorder present in almost all countries. According to WHO, T2DM is the World’s fifth leading cause of death. Treatment for T2DM depends on the incretin hormone (GLP-1 &amp; GIP). GLP-1 plays a vital role in the body’s metabolism, such as insulin secretion but DPP-IV enzyme inactivates these incretin hormones. Therefore, it becomes important to identify DPP-IV inhibitors that act as prospective antidiabetic agents. Synthetic inhibitors like vildagliptin, sitagliptin, and saxagliptin are available in the market but they have some undesirable side effects. There are several natural plants as well as products that provide safe and effective medication against diabetes by DPP-IV enzyme inhibitory mechanism. This review summarizes recent advancement of DPP-IV inhibitors from medicinal plants and isolated phytoconstituents including alkaloids, flavonoids, terpenoids, phenol, and stilbenoids which are responsible for the DPP-IV inhibition.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-05-08 21:02:28
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/24633
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 4 (2019): December 2019
 
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