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<p style="text-align: justify;">Antipsoriatic activity of <em>Cassia auriculata </em>L. flowers in Freund’s adjuvantformaldehyde induced animal model</p>

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Title Statement <p style="text-align: justify;">Antipsoriatic activity of <em>Cassia auriculata </em>L. flowers in Freund’s adjuvantformaldehyde induced animal model</p>
 
Added Entry - Uncontrolled Name lakshmi, Vijaya ; School of Pharmaceutical Sciences vels University Pallavaram, Chennai-117, tamilnadu
M, Priyanka ; Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai 600117, Tamil Nadu, India
S, Priyadharshini ; Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai 600117, Tamil Nadu, India
S, Sathish Kumar; Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai 600117, Tamil Nadu, India
S, Jayakumari ; Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai 600117, Tamil Nadu, India
Supported by Vels Institute of Science and Technology
 
Uncontrolled Index Term Pharmaceutical Sciences
Cassia auriculata L.; Complete Freund’s Adjuvant; Herbal ointment; Psoriasis.
 
Summary, etc. <p style="text-align: justify;">The plant <em>Cassia auriculata </em>L. belonging to the family Caesalpiniaceae (Leguminosae) used in the Ayurvedic system of medicine for the treatment of diabetes, ulcers, leprosy, conjunctivitis, liver and skin diseases. The present study aimed to evaluate the antipsoriatic effect of the ointments 0.5 and 1.0% (w/w) containing ethanol extract of the flowers of <em>C. auriculata </em>using complete Freund's adjuvant (CFA) and induced animal model and also evaluated for its physical parameters. Antipsoriatic effect of 0.5 and 1.0% (w/w) ointments was evaluated by the phenotypic features (redness, erythema, and scales) in terms of psoriasis severity index (PSI) and histological features (epidermal thickness and degree of orthokeratosis). Evaluation of physical parameters for the prepared ointments showed satisfactory results with an acceptable condition of consistency for application. 0.5 and 1.0% (w/w) ointments treated animals showed a significant (*<em>P </em>&lt;0.05) increase in the orthokeratinocyte layer and a significant (<em>**P </em>&lt;0.01) reduction in the epidermal layer of skin treated with 1.0% (w/w) ointment with a progressive reduction (<em>**P </em>&lt;0.01) in the severity of psoriatic lesions (erythema, redness, and scales) from day 7 to 21st day. The present investigations revealed that the flowers of <em>Cassia auriculata </em>possess antipsoriatic activity, confirming their traditional use in skin disorders.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-05-08 21:02:28
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/24470
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 4 (2019): December 2019
 
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