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Analysis of RIG-I-mediated innate immune response in rats with Kidney-Yang Deficiency Syndrome and its change following Yougui pill administration

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Title Statement Analysis of RIG-I-mediated innate immune response in rats with Kidney-Yang Deficiency Syndrome and its change following Yougui pill administration
 
Added Entry - Uncontrolled Name Zhao, Min
Huang, Min
Liu, Junfeng
Xiao, Min
Yu, Xiaoming
Zhou, Yanyan
Tan, Aihua
 
Uncontrolled Index Term Interleukin-6; Kidney-Yang deficiency syndrome; Retinoic acid-inducible gene-I; Tripartite motif containing 25; Tumor necrosis factor-α; Yougui pill
 
Summary, etc. Kidney-Yang Deficiency Syndrome (KYDS) is closely bound up with the immune response of immunocompromised patients. The study is to investigate whether retinoic acid-inducible gene-I (RIG-I)-mediated innate immune responseparticipates in the development of KYDS in rats and evaluate the effect of Yougui pill (YGP) on the response in KYDS rats. KYDS rats were induced by intramuscular injection of hydrocortisone at the dose of 10 mg/kg/d for 15 days. YGP at concentrations of 2.43 g/kg/d and 4.86 g/kg/d were administered intragastrically to KYDS rats for 30 days. The results<br />showed that the body weight, urinary 17-hydroxycorticosteroid (17-OHCS) level, spleen size and spleen index in KYDS rats were significantly decreased compared with healthy control rats, while YGP treatment reversed them towards normal level in a dose-dependent manner. Moreover, KYDS challenge not only strikingly increased the mRNA and protein expression levels of RIG-I, tripartite motif containing 25 (TRIM25), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) but also<br />markedly enhanced the endogenous RIG-I polyubiquitination levels. Whereas, YGP treatment effectively reversed this tendency in a dose-dependent manner. In conclusion, these findings revealed that RIG-I-mediated innate immune response was closely bound up with the development of KYDS. And YGP exhibited certain anti-inflammatory effects on KYDS rats via inhibiting the RIG-I-mediated innate immune response.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-05-16 12:03:22
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/35350
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 2 (2020): Indian Journal of Traditional Knowledge
 
Language Note en