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Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds

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Title Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds
 
Creator Bovine HapMap Consortium
 
Subject GENOMES
CATTLE
 
Description The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.
 
Date 2010-07-05T19:37:40Z
2010-07-05T19:37:40Z
2009-04-29
 
Type Journal Article
 
Identifier Bovine HapMap Consortium. 2009. Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science 324(5926):528-532.
0036-8075
http://hdl.handle.net/10568/2020
 
Language en
 
Source Science