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Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons

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Title Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons
 
Creator Kemp, Stephen J.
Hanotte, Olivier H.
Agaba, Morris
Noyes, H.A.
Gibson, John P.
Archibald, A.L.
Rennie, C.
Hulme, H.
Brass, A.
 
Subject TRYPANOSOMOSIS
ANIMAL DISEASES
 
Description An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in both cattle and mice. The approach uses expression analysis to examine the response of both susceptible and resistant strains and a series of novel informatics tools to identify pathways which are activated as a result of challenge, and those which are differentially used by resistant and susceptible strains. Of particular interest are those pathways which simultaneously satisfy both criteria, i.e. are significantly differentially activated and contain genes within QTL regions. However, it is important to stress that it is not required that the genes within the QTL region are differentially expressed themselves.
 
Date 2010-04-21T12:40:18Z
2010-04-21T12:40:18Z
2008
 
Type Journal Article
 
Identifier Kemp, S.J.; Hanotte, O.; Agaba, M.; Noyes, H.A.; Gibson, J.; Archibald, A.; Rennie, C.; Hulme, H.; Brass, A. 2008. Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons . Developments in Biologicals 132:89-91.
http://hdl.handle.net/10568/1307
 
Language en
 
Source Developments in Biologicals