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Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle

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Title Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle
 
Creator Freeman, A.R.
Bradley, D.G.
Nagda, S.
Gibson, John P.
Hanotte, Olivier H.
 
Subject GENETICS
CATTLE
 
Description S. Nagda, J.P. Gibson and O. Hanotte are ILRI authors
Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data sets or Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data sets or comparison of population genetic parameters from different studies and breeds has proven difficult. Often different genotyping methods have been employed, preventing standardization of microsatellite allele calling. In other cases different sets of markers have been genotyped, providing differing estimates of population genetic parameters. Here, we address these issues and illustrate a general two-step regression approach in cattle using three different sets of microsatellite data, to combine population genetics estimates of diversity and admixture. This regression-based method is independent of the loci genotyped but requires common breeds in the data sets. We show that combining microsatellite data sets can provide new insights on the origin and geographical distribution of genetic diversity and admixture in cattle, which will facilitate global management of this livestock species.comparison of population genetic parameters from different studies and breeds has proven difficult. Often different genotyping methods have been employed, preventing standardization of microsatellite allele calling. In other cases different sets of markers have been genotyped, providing differing estimates of population genetic parameters. Here, we address these issues and illustrate a general two-step regression approach in cattle using three different sets of microsatellite data, to combine population genetics estimates of diversity and admixture. This regression-based method is independent of the loci genotyped but requires common breeds in the data sets. We show that combining microsatellite data sets can provide new insights on the origin and geographical distribution of genetic diversity and admixture in cattle, which will facilitate global management of this livestock species.
 
Date 2010-05-06T08:56:34Z
2010-05-06T08:56:34Z
2006-08-26
 
Type Journal Article
 
Identifier Freeman, A.R.; Bradley, D.G.; Nagda, S.; Gibson, J.P.; Hanotte, O. 2006. Combination of multiple microsatellite datasets to investigate genetic diversity and admixture of domestic cattle. Animal Genetics 37(1):1-9.
0268-9146
http://hdl.handle.net/10568/1383
 
Language en
 
Source Animal Genetics