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The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene

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Title The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene
 
Creator Kitani, H.
Yagi, Y.
Naessens, Jan
Sekikawa, K.
Iraqi, F.A.
 
Subject GENETICS
ANIMAL DISEASES
 
Description Tumor necrosis factor-α (TNF-α) plays a role in the host’s defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can influence parasitemia and survival are unknown. Therefore, the levels of acute phase proteins and other inflammatory cytokines were monitored in trypano-tolerant wild-type and TNF-α-deficient mice during a T. congolense infection.
The titres of ceruloplasmin (CP), α1-acid glycoprotein (AGP) and serum amyloid P (SAP) increased and reached their peaks at 11 days post-infection, when the first peak of parasitemia was observed. No significant differences were observed in the acute phase protein profiles between the two mouse strains. Also the profiles of serum titres of IFN-γ, IL-1α, IL-6 and IL-10 were not significantly different. Our present results indicate that acute phase protein and cytokine responses can be induced in the absence of TNF-α during a T. congolense infection in mice, and that the susceptibility of the TNF-α-deficient mice is not due to modulation of expression of these molecules.
 
Date 2010-05-11T06:33:05Z
2010-05-11T06:33:05Z
2004-09-15
 
Type Journal Article
 
Identifier Kitani, H.; Yagi, Y.; Naessens, J.; Sekikawa, K.; Iraqi, F. 2004. The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-gene. Acta Tropica 92:35-42.
http://hdl.handle.net/10568/1476
 
Language en
 
Source Acta Tropica