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Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

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Title Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
 
Creator Hanotte, Olivier H.
Ronin, Y.
Agaba, Morris
Nilsson, P.
Gelhaus, A.
Horstmann, R.
Sugimoto, Y.
Kemp, Stephen J.
Gibson, John P.
Korol, A.
Soller, M.
Teale, A.
 
Subject TRYPANOSOMOSIS
CATTLE
 
Description Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible improved Kenya Boran (Bos indicus) cattle. Sixteen phenotypic traits were defined describing anemia, body weight, and parasitemia. One hundred seventy-seven F2 animals and their parents and grandparents were genotyped at 477 molecular marker loci covering all 29 cattle autosomes. Total genome coverage was 82%. Putative QTL were mapped to 18 autosomes at a genomewise false discovery rate of
 
Date 2010-06-13T16:10:53Z
2010-06-13T16:10:53Z
2003-06-24
 
Type Journal Article
 
Identifier Hanotte, O.; Ronin, Y.; Agaba, M.; Nilsson, P.; Gelhaus, A.; Horstmann, R.; Sugimoto, Y.; Kemp, S.; Gibson, J.; Korol, A.; Soller, M.; Teale, A. 2003. Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. PNAS 100(13):7443-7448.
0027-8424
http://hdl.handle.net/10568/1870
 
Language en
 
Source Proceedings of the National Academy of Sciences of the United States of America