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Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility

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Title Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility
 
Creator O'Gorman, G.M.
Park, S. de
Hill, E.W.
Meade, K.G.
Coussens, P.M.
Agaba, Morris
Naessens, Jan
Kemp, Stephen J.
MacHugh, D.E.
 
Subject TRYPANOSOMA CONGOLENSE
TRYPANOSOMIASIS
EXPERIMENTATION
GENES
 
Description Morris Agaba & Jan Naessens are ILRI authors
African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and agricultural production in Africa and is among the top ten global cattle diseases impacting on the poor. Here we show that a functional genomics approach can be used to identify temporal changes in host peripheral blood mononuclear cell (PBMC) gene expression due to disease progression. We also show that major gene expression differences exist between cattle from trypanotolerant and trypanosusceptible breeds. Using bovine long oligonucleotide microarrays and real time quantitative reverse transcription PCR (qRT-PCR) validation we analysed PBMC gene expression in naïve trypanotolerant and trypanosusceptible cattle experimentally challenged with Trypanosoma congolense across a 34-day infection time course.
 
Date 2009-11-01T09:11:47Z
2009-11-01T09:11:47Z
2009-05-01
 
Type Journal Article
 
Identifier O'Gorman, G.; Park, S. de; Hill, E.W.; Meade, K.G.; Coussens, P.M.; Agaba, M.; Naessens, J.; Kemp, S.J.; MacHugh, D.E. 2009. Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility. BMC Genomics. v. 10. p. 207.
http://hdl.handle.net/10568/45
 
Language en
 
Source BMC Genomics