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Genetic mapping of quantitative trait loci for resistance to Haemonchus contortus in sheep

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Title Genetic mapping of quantitative trait loci for resistance to Haemonchus contortus in sheep
 
Creator Marshall, Karen
Maddox, J.F.
Lee, S.H.
Zhang, Y.
Graser, H.U
Gondro, C.
Walken-Brown, S.W.
Werf, J.H.J. van der
 
Subject DISEASE RESISTANCE
SHEEP
 
Description This paper presents results from a mapping experiment to detect quantitative trait loci (QTL) for resistance to Haemonchus contortus infestation in merino sheep. The primary trait analysed was faecal worm egg count in response to artificial challenge at 6 months of age. In the first stage of the experiment, whole genome linkage analysis was used for broad-scale mapping. The animal resource used was a designed flock comprising 571 individuals from four half-sib families. The average marker spacing was about 20 cM. For the primary trait, 11 QTL (as chromosomal/family combinations) were significant at the 5% chromosome-wide level, with allelic substitution effects of between 0.19 and 0.38 phenotypic standard deviation units. In general, these QTL did not have a significant effect on faecal worm egg count recorded at 13 months of age. In the second stage of the experiment, three promising regions (located on chromosomes 1, 3 and 4) were fine-mapped. This involved typing more closely spaced markers on individuals from the designed flock as well as an additional 495 individuals selected from a related population with a deeper pedigree. Analysis was performed using a linkage disequilibrium–linkage approach, under additive, dominant and multiple QTL models. Of these, the multiple QTL model resulted in the most refined QTL positions, with resolutions of
 
Date 2010-08-09T19:00:40Z
2010-08-09T19:00:40Z
2009-03-05
 
Type Journal Article
 
Identifier Marshall, K.; Maddox, J.F.; Lee, S.H.; Zhang, Y.; Kahn, L.; Graser, H.-U.; Gondro, C.; Walkden-Brown, S.W.; Werf, J.H.J. van der. 2009. Genetic mapping of quantitative trait loci for resistance to Haemonchus contortus in sheep. Animal Genetics 40(3):262-272.
0268-9146
http://hdl.handle.net/10568/2229
 
Language en
 
Source Animal Genetics