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TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection

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Title TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
 
Creator Naessens, Jan
Kitani, H.
Nakamura, Y.
Yagi, Y.
Sekikawa, K.
Iraqi, F.A.
 
Subject TRYPANOSOMIASIS
DISEASE CONTROL
 
Description Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develops very early in infection around the time when parasites become detectable in the blood. Since the anaemia persists after the first waves of parasitaemia when low numbers of trypanosomes are circulating in the blood, it is generally assumed that anaemia is not directly induced by a parasite factor, but might be cytokine-mediated, as in other cases of anaemia accompanying inflammation. To clarify the role of TNF-α in the development of anaemia, blood parameters of wild type (TNF-α+/+), TNF-α-null (TNF-α-/-) and TNF-α-hemizygous (TNF-α-/+) trypanotolerant mice were compared during infections with the cattle parasite Trypanosoma congolense. No differences in PCV, erythrocyte numbers or haemoglobin were observed between TNF-α-deficient and wild type mice, suggesting that the decrease in erythrocytes was not mediated by TNF-α. Erythropoetin (EPO) levels increased during infection and no significant differences in EPO levels were observed between the three mouse strains. In contrast, during an infection with the human pathogen Trypanosoma brucei rhodesiense, the number of red blood cells in TNF-α-deficient mice remained significantly higher than in the wild type mice. These data suggest that more than one mechanism promotes the development of anaemia associated with trypanosomiasis.
 
Date 2010-05-09T19:14:46Z
2010-05-09T19:14:46Z
2005-01-28
 
Type Journal Article
 
Identifier Naessens, J.; Kitani, H.; Nakamura, Y.; Yagi, Y.; Sekikawa, K.; Iraqi, F. 2005. TNF mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection. Clinical and Experimental Immunology 139:405-410.
http://hdl.handle.net/10568/1434
 
Language en
 
Source Clinical & Experimental Immunology