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Trypanocidal failure suggested by PCR results in cattle field samples

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Title Trypanocidal failure suggested by PCR results in cattle field samples
 
Creator Gall, Y.
Woitag, T.
Bauer, B.
Sidibe, I.
McDermott, John J.
Mehlitz, D.
Clausen, P.H.
 
Subject PHYTOMONAS
TRYPANOSOMIASIS
ANTIPROTOZOAL AGENTS
THERAPY
PCR
CATTLE
 
Description The aim of this study was to assess, whether polymerase chain reaction (PCR) allows sensitive screening of treatment failure suspicions in areas, where drug resistance against African animal trypanosomosis (AAT) appears to be a problem. PCR was used to detect trypanosome infections prior to, 14 and 28 days after controlled treatment of 738 cattle from 10 villages in Kenedougou, Burkina Faso with isometamidium chloride and diminazene aceturate. Using three sets of primers, PCR was three-four times more sensitive and better at species identification, than standard microscopic examination. The better sensitivity and species specificity of PCR have important advantages for drug resistance studies in the field.
 
Date 2013-06-11T09:25:39Z
2013-06-11T09:25:39Z
2004
 
Type Journal Article
 
Identifier Acta Tropica;92(1): 7-16
0001-706X
http://hdl.handle.net/10568/29971
 
Language en
 
Source Acta Tropica