Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
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Title |
Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
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Creator |
Cox, S.E.
Makani, J. Soka, D. L'Esperance, V.S. Kija, E. DomÃnguez-Salas, Paula Newton, C.R.J. Birch, A.A. Prentice, A.M. Kirkham, F.J. |
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Subject |
PATHOLOGY
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Description |
Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co-inheritance in SCA of alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co-inheritance of these polymorphisms on CBFv in 601 stroke-free Tanzanian SCA patients aged
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Date |
2014-12-17T07:03:59Z
2014-12-17T07:03:59Z 2014-02-21 |
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Type |
Journal Article
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Identifier |
Cox, S.E., Makani, J., Soka, D., L'Esperance, V.S., Kija, E., Dominguez-Salas, P., Newton, C.R.J., Birch, A.A., Prentice, A.M. and Kirkham, F.J. 2014. Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania. British Journal of Haematology 165(5): 699-706.
1365-2141 http://hdl.handle.net/10568/52228 |
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Language |
en
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Source |
British Journal of Haematology
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