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Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania

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Title Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
 
Creator Cox, S.E.
Makani, J.
Soka, D.
L'Esperance, V.S.
Kija, E.
Domínguez-Salas, Paula
Newton, C.R.J.
Birch, A.A.
Prentice, A.M.
Kirkham, F.J.
 
Subject PATHOLOGY
 
Description Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co-inheritance in SCA of alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co-inheritance of these polymorphisms on CBFv in 601 stroke-free Tanzanian SCA patients aged
 
Date 2014-12-17T07:03:59Z
2014-12-17T07:03:59Z
2014-02-21
 
Type Journal Article
 
Identifier Cox, S.E., Makani, J., Soka, D., L'Esperance, V.S., Kija, E., Dominguez-Salas, P., Newton, C.R.J., Birch, A.A., Prentice, A.M. and Kirkham, F.J. 2014. Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania. British Journal of Haematology 165(5): 699-706.
1365-2141
http://hdl.handle.net/10568/52228
 
Language en
 
Source British Journal of Haematology