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Associations between common variants in iron-related genes with haematological traits in populations of African ancestry

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Title Associations between common variants in iron-related genes with haematological traits in populations of African ancestry
 
Creator Gichohi-Wainaina, Wanjiku N.
Tanaka, Toshiko
Towers, G. Wayne
Verhoef, Hans
Veenemans, Jacobien
Talsma, Elise F.
Harryvan, Jan
Boekschoten, Mark V.
Feskens, Edith J.M.
Melse-Boonstra, Alida
 
Subject diet
ferritin
genotypes
deficiencies
iron
inflammation
population genetics
genomics
ferritín
genotipos
hierro
inflamación
genética de poblaciones
genómica
 
Description Background
Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations.
Methods
We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels.
Results
In the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P =
 
Date 2016-06-22
2016-07-22T23:14:58Z
2016-07-22T23:14:58Z
 
Type Journal Article
 
Identifier Gichohi-Wainaina, Wanjiku N.; Tanaka, Toshiko; Towers, G. Wayne; Verhoef, Hans; Veenemans, Jacobien; Talsma, Elise; Harryvan, Jan; Boekschoten, Mark V.; Feskens, Edith J.; Melse-Boonstra, Alida. 2016. Associations between common variants in iron-related genes with haematological traits in populations of African ancestry . PLoS ONE 11(6): e0157996.
1932-6203
https://hdl.handle.net/10568/76253
https://doi.org/10.1371/journal.pone.0157996
 
Language en
 
Rights CC0-1.0
Open Access
 
Format 11(6): e0157996
 
Publisher Public Library of Science (PLoS)
 
Source PLOS ONE