ICAR Research Data Repository for Knowledge Management
A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
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View Archive Info| Field | Value | |
| Title |
A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
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| Creator |
Graham, S.P.
Honda, Y. Pelle, Roger Mwangi, D.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath Taracha, E.L.N. |
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| Subject |
animal diseases
disease control |
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| Description |
Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL.
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| Date |
2007
2010-05-06T09:07:49Z 2010-05-06T09:07:49Z |
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| Type |
Journal Article
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| Identifier |
Graham, S.P.; Honda, Y.; Pelle, R. et al. 2007. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immunome Research 3:2.
1745-7580 https://hdl.handle.net/10568/1394 https://doi.org/10.1186/1745-7580-3-2 |
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| Language |
en
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| Rights |
Open Access
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| Publisher |
Springer
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| Source |
Immunome Research
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