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Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

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Title Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
 
Creator Pain, A.
Renauld, H.
Berriman, M.
Murphy, L.
Yeats, C.A.
Weir, W.
Kerhornou, A.
Aslett, M.
Bishop, Richard P.
Bouchier, C.
Cochet, M.
Coulson, R.M.R.
Cronin, A.
Villiers, Etienne P. de
Fraser, A.
Fosker, N.
Gardner, M.
Goble, A.
Griffiths-Jones, S.
Harris, D.E.
Katzer, F.
Larke, N.
Lord, A.
Maser, P.
McKellar, S.
Mooney, P.
Morton, F.
Nene, Vishvanath
O'Neil, S.
Price, C.
Quail, M.A.
Rabbinowitsch, E.
Rawlings, N.D.
Rutter, S.
Saunders, D.
Seeger, K.
Shah, Tushaar
Squares, R.
Squares, S.
Tivey, A.
Walker, A.R.
Woodward, J.
Dobbelaere, D.A.E.
Langsley, G.
Rajandream, M.A.
McKeever, Declan J.
Shiels, B.
Tait, A.
Barrell, B.
Hall, N.
 
Subject parasites
theileria annulata
theileria parva
 
Description Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
 
Date 2005-07
2012-07-09T05:42:17Z
2012-07-09T05:42:17Z
 
Type Journal Article
 
Identifier Pain, A., Renauld, H., Berriman, M., Murphy, L., Yeats, C.A., Weir, W., Kerhornou, A., Aslett, M., Bishop, R., Bouchier, C., Cochet, M., Coulson, R.M.R., Cronin, A., Villiers, E. de, Fraser, A., Fosker, N., Gardner, M., Goble, A., Griffiths-Jones, S., Harris, D.E., Katzer, F., Larke, N., Lord, A., Maser, P., McKellar, S., Mooney, P., Morton, F., Nene, V., O’Neil, S., Price, C., Quail, M.A., Rabbinowitsch, E., Rawlings, N.D., Rutter, S., Saunders, D., Seeger, K., Shah, T., Squares, R., Squares, S., Tivey, A., Walker, A.R., Woodward, J., Dobbelaere, D.A.E., Langsley, G., Rajandream, M., McKeever, D., Shiels, B., Tait, A., Barrell, B. and Hall, N. 2005. Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science 309:131.
0036-8075
1095-9203
https://hdl.handle.net/10568/21171
https://doi.org/10.1126/science.1110418
 
Language en
 
Rights Limited Access
 
Publisher American Association for the Advancement of Science
 
Source Science