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Potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity

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Title Potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity
 
Creator Akkari, Hafidh
 
Contributor B’chir, Fatma
Hajaji, Soumaya
Rekik, Mourad
Sebai, E.
Hamza, Kanar
Darghouth, Mohamed Aziz
Gharbi, Mohamed
 
Subject anthelmintic
free radical-scavenging ability
 
Description Capparis spinosa is cultivated for several proprieties and the different parts of the plant (flower buds,
fruits, leaf and seeds) have been employed in drugs, foods and cosmetics. This study aimed to explore the antioxidant
potential effect and to assess the anthelmintic efficacy of an aqueous extract of Capparis spinosa. In vitro
antioxidant activity of aqueous extracts from the fresh leaves and flower buds of C. spinosa was measured by
determining free radical-scavenging activity against DPPH and ABTS radical cations. In vitro anthelmintic activities
against eggs and adult worms of Haemonchus contortus from sheep were investigated in comparison to
albendazole. DPPH and ABTS activities of both aqueous extracts increased in a dose dependent manner. The
IC50 values of aqueous extracts from fresh leaves, flowers buds and ascorbic acid in the DPPH radical scavenging
assay were 101.40; 70.40 and 57.56 μg/ml, respectively. The IC50 values of aqueous extracts fresh leaves, flowers
buds and ascorbic acid in the ABTS radical scavenging assay were 110; 87.89 and 58.17 μg/ml, respectively. Both
plant extracts showed ovicidal activity at all tested concentrations. The aqueous extract from flower buds (IC50 =
2.76 mg/ml) showed higher inhibitory effects (P < 0.05) than aqueous extract from leaves (IC50 = 8.54 mg/ml) in
the egg hatching assay. The aqueous extract from flower buds inhibited more worms than the aqueous extract from
leaves at all tested concentrations. After 6 h of exposure, the highest tested concentrations of aqueous extracts
from flower buds and leaves induced 100 and 41.66% inhibition of motility, respectively. These results show for
the first time that C. spinosa possesses in vitro anthelmintic properties which may be related to its high content
of phenolic compounds such as flavonoids and tannins.
 
Date 2016-11-27
2017-03-04T22:02:18Z
2017-03-04T22:02:18Z
 
Type Journal Article
 
Identifier http://www.agriculturejournals.cz/web/vetmed.htm?type=article&id=169_2015-VETMED
https://www.researchgate.net/publication/305370829_Potential_anthelmintic_effect_of_Capparis_spinosa_Capparidaceae_as_related_to_its_polyphenolic_content_and_antioxidant_activity
https://mel.cgiar.org/reporting/download/hash/kgKxBmD4
Hafidh Akkari, Fatma B’chir, Soumaya Hajaji, Mourad Rekik, E. Sebai, Kanar Hamza, Mohamed Aziz Darghouth, Mohamed Gharbi. (27/11/2016). Potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity. Veterinární Medicína, 61 (6), pp. 308-316.
https://hdl.handle.net/20.500.11766/6140
Open access
 
Language en
 
Rights CC-BY-NC-4.0
 
Format PDF
 
Publisher Czech Academy of Agricultural Sciences
 
Source Veterinární Medicína;61,(2016) Pagination 308-316