Record Details


Field	Value

Title	Genetic prediction of complex traits: integrating infinitesimal and marked genetic effects

Names	Carre, C. Gamboa, F. Cros, D. Hickey, J.M. Gorjanc, G. Manfredi, E.
Date Issued	2013 (iso8601)
Abstract	Genetic prediction for complex traits is usually based on models including individual (infinitesimal) or marker effects. Here, we concentrate on models including both the individual and the marker effects. In particular, we develop a ?Mendelian segregation? model combining infinitesimal effects for base individuals and realized Mendelian sampling in descendants described by the available DNA data. The model is illustrated with an example and the analyses of a public simulated data file. Further, the potential contribution of such models is assessed by simulation. Accuracy, measured as the correlation between true (simulated) and predicted genetic values, was similar for all models compared under different genetic backgrounds. As expected, the segregation model is worthwhile when markers capture a low fraction of total genetic variance.
Genre	Article
Access Condition	Open Access
Identifier	0016-6707

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