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Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

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Title Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment
 
Creator Kim, Eui-Soo
 
Contributor Elbeltagy, Ahmed R.
Adel M. Aboul-Naga, Adel
Rischkowsky, Barbara
Sayre, Brian
Mwacharo, Joram
Rothschild, Max F.
 
Subject genetic
indigenous
 
Description Goats and sheep are versatile domesticates that have been integrated into diverse environments and production systems.
Natural and artificial selection have shaped the variation in the two species, but natural selection has played the major role among indigenous flocks. To investigate signals of natural selection, we analyzed genotype data generated using the caprine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid environment in Egypt’s Coastal Zone of the Western Desert. We identify several candidate regions under selection that spanned 119 genes. A majority of the genes were involved in multiple signaling and signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified. We also identified eight common candidate genes under selection in the two species and a shared selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and ovine chromosomes 12 and 10, respectively, providing, most likely, the evidence for selection in a common environment in two different but closely related species. Our study highlights the importance of indigenous livestock as model organisms for investigating selection sweeps and genome-wide association mapping.
 
Date 2016-02-27
2017-03-12T22:55:54Z
2017-03-12T22:55:54Z
 
Type Journal Article
 
Identifier https://www.nature.com/articles/hdy201594
https://mel.cgiar.org/reporting/download/hash/PR7AD86a
Eui-Soo Kim, Ahmed R. Elbeltagy, Adel Adel M. Aboul-Naga, Barbara Rischkowsky, Brian Sayre, Joram Mwacharo, Max F. Rothschild. (27/2/2016). Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment. Heredity, 116, pp. 255-264.
https://hdl.handle.net/20.500.11766/6437
Open access
 
Language en
 
Rights CC-BY-4.0
 
Format PDF
 
Publisher Nature Publishing Group: Open Access Hybrid Model Option B
 
Source Heredity;116,(2016) Pagination 255,264