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Bioactive chemicals from marine organisms - Extraction and analysis

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Relation http://eprints.cmfri.org.in/7572/
 
Title Bioactive chemicals from marine organisms -
Extraction and analysis
 
Creator Rajendran, I
 
Subject Theses
Bioactive compound
 
Description Marine natural products chemistry emerging as a multidisciplinary field
drawing attention of chemists, along with pharmacologists and biologists is to explore
compounds of novel features both in structure and biological activities. The recent trend
of more biological screening along with structural identification of the compounds
present in extracts of marine organisms shows that there is increased potential application
of these secondary metabolites. The richness in marine bio diversity as the source of
various biologically active compounds is now felt extensively.
Gulf of Mannar Marine Biosphere Reserve (GOMMBR) present in South East
Indian Coastal area has the coastal bio diversity housing appreciable number of various
marine organisms. Though the GOMMBR is rich in various flora and fauna, work on the
chemical aspects of its organisms is not well explored. At present, reports on Alcyonarian
corals of this region are coming, but reports on sponges and finfishes are very scarce.
This thesis describes the first chemical investigation of the marine organisms of
Palk Bay, viz. sponges and a puffer fish. The organisms investigated in this thesis include
five genera of sponges viz. Siphollochalina spp., Cervicornia spp., Hippospongia spp.,
Hyrlios spp. and Spongia spp. and puffer fish, Telraodon spp. The analyses have been
carried out using GC-MS and most of the compounds have been characterized by their
mass spectra by comparison with the data of standard compounds.
The third chapter describes the chemical study of Siphonochalina. spp. Three
fractions obtained have been analysed and nine compounds have been characterised from
the first fraction, one each from rhe other two fractions.
The fourth chapter descnbes the identification of compounds from three fractions
collected from Cervicomia spp. Eleven fatty acid methyl esters, eight free fatty acids and
ten other compounds have been found to be present respectively in these fractions.
The fifth chapter deals with the chemical exploration of Hippospongia spp.
isolating four fractions from the petroleum ether extract. There are nine compounds in
first fraction, nine compounds in second fraction, two from the third and five from the
last fraction. Different long chain hydrocarbons, long chain fatty acid methyl esters and
steroids have been identified from these fractions.
 
Date 2005
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://eprints.cmfri.org.in/7572/1/TH-145.pdf
Rajendran, I (2005) Bioactive chemicals from marine organisms - Extraction and analysis. ["eprint_fieldopt_thesis_type_phd" not defined] thesis, Madurai Kamaraj University, Madurai.