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Contrasting evolution of diversity at two disease-associated chicken genes

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Title Contrasting evolution of diversity at two disease-associated chicken genes
 
Creator Downing, T.
Lynn, D.J.
Connell, S.
Lloyd, A.T.
Bhuiyan, A.K.F.H.
Silva, P.
Naqvi, A.N.
Sanfo, R.
Sow, R.S.
Overseas Development Institute
O'Farrelly, C.O.
Hanotte, Olivier H.
Bradley, D.G.
 
Subject CHICKENS
DISEASE RESISTANCE
 
Description Olivier Hanotte is ILRI author
There have been significant evolutionary pressures on the chicken during both its speciation and its subsequent domestication by man. Infectious diseases are expected to have exerted strong selective pressures during these processes. Consequently, it is likely that genes associated with disease susceptibility or resistance have been subject to some form of selection. Two genes involved in the immune response (interferon-γ and interleukin 1-β) were selected for sequencing in diverse chicken populations from Pakistan, Sri Lanka, Bangladesh, Kenya, Senegal, Burkina Faso and Botswana, as well as six outgroup samples (grey, green, red and Ceylon jungle fowl and grey francolin and bamboo partridge). Haplotype frequencies, tests of neutrality, summary statistics, coalescent simulations and phylogenetic analysis by maximum likelihood were used to determine the population genetic characteristics of the genes. Networks indicate that these chicken genes are most closely related to the red jungle fowl. Interferon-γ had lower diversity and considerable coding sequence conservation, which is consistent with its function as a key inflammatory cytokine of the immune response. In contrast, the pleiotropic cytokine interleukin 1-β had higher diversity and showed signals of balancing selection moderated by recombination, yielding high numbers of diverse alleles, possibly reflecting broader functionality and potential roles in more diseases in different environments.
 
Date 2010-01-16T20:47:13Z
2010-01-16T20:47:13Z
2009-04-15
 
Type Journal Article
 
Identifier Downing, T.; Lynn, D.J.; Connell, S.; Lloyd, A.T.; Bhuiyan, A.F.H.; Silva, P.; Naqvi, A.N.; Sanfo, R.; Sow, R.-S.; Podisi, B.; O’Farrelly, C.; Hanotte, O.; Bradley, D.G. 2009. Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics. v. 61(4). p. 303-314.
0093-7711
1432-1211
https://hdl.handle.net/10568/474
 
Language en
 
Source Immunogenetics