ICAR Research Data Repository for Knowledge Management
A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation
CGSpace Test
View Archive Info| Field | Value | |
| Title |
A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation
|
|
| Creator |
Fisher, P.
Noyes, H. Kemp, Stephen J. Stevens, R. Brass, A. |
|
| Description |
It is increasingly common to combine genome-wide expression data with quantitative trait mapping data to aid in the search for sequence polymorphisms responsible for phenotypic variation. By joining these complex but different data types at the level of the biological pathway, we can take advantage of existing biological knowledge to systematically identify possible mechanisms of genotype–phenotype interaction. With the development of web services and workflows, this process can be made rapid and systematic. Our methodology was applied to a use case of resistance to African trypanosomiasis in mice. Workflows developed in this investigation, including a guide to loading and executing them with example data, are available at http://www.myexperiment.org/users/43/workflows.
|
|
| Date |
2010-04-21T13:01:56Z
2010-04-21T13:01:56Z 2009-09-18 |
|
| Type |
Book Chapter
|
|
| Identifier |
Fisher P., Noyes H., Kemp S., Stevens R. and Brass A. 2009. A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation Methods in Molecular Biology. IN: Cardiovascular Genomics: Methods and protocols. Dordrecht: Springer: 329-345
1064-3745 https://hdl.handle.net/10568/1313 |
|
| Language |
en
|
|
| Publisher |
Springer
|
|