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Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti

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Title Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti
 
Creator Jeong, W.
Kweon, C.H.
Kwang, S.W.
Hu Suk Lee
Xu, Y.
Lu, C.
Zhang, S.
Nene, Vishvanath
 
Subject disease control
theileria sergenti
 
Description In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33). The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector. The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle. HSP-p33 fusion protein provoked higher humoral and cellular immunity than either Escherichia coli-expressed p33 or piroplasm soluble protein. The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle. The overall growth of parasites in cattle was significantly restrained in the HSP-p33-inoculated group, up to 50-52 days longer than in the controls. The present results indicate that HSP-p33 fusion protein is a promising candidate vaccine for clinical theileriosis in the field.
 
Date 2009-10-15
2010-06-13T16:12:38Z
2010-06-13T16:12:38Z
 
Type Journal Article
 
Identifier Jeong, W.; Kweon, C.H.; Kang, S.W.; Lee, H.S.; Xu, Y.; Lu, C.; Zhang, S.; Nene, V. 2009. Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein p33 of Theileria sergenti. Biologicals 37(5):282-287.
1045-1056
https://hdl.handle.net/10568/1873
https://doi.org/10.1016/j.biologicals.2009.04.003
 
Language en
 
Rights Limited Access
 
Format p. 282-287
 
Source Biologicals