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Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense

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Title Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense
 
Creator Kazuhiro, Y.
Agaba, Morris
Iraqi, F.A.
Naessens, Jan
 
Subject TRYPANOSOMIASIS
CATTLE
 
Description It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro and the expressions of a number of cytokines and iNOS mRNA were analyzed using real time RT-PCR after stimulation with antibody-opsonized trypanosomes. No significant difference was seen between the responses of the two breeds. However, RNA levels of TNF-α in the IFN-γ-primed macrophages were about 100-fold higher than those in the non-primed macrophages. A significant ten-fold decrease was seen for the anti-inflammatory cytokine IL-10. These results indicate that priming of the cells with IFN-y cause a serious shift toward an inflammatory response.
 
Date 2010-05-18T20:14:33Z
2010-05-18T20:14:33Z
2007
 
Type Journal Article
 
Identifier Yoshihara, K.; Agaba, M.; Iraqi, F.; Naessens, J. 2007. Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense. Journal of the Veterinary Medical Science (Japan) 69:421-423.
0916-7250
https://hdl.handle.net/10568/1543
 
Language en
 
Source Journal of Veterinary Medical Science