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Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes

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Title Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
 
Creator Graham, S.P.
Pelle, Roger
Honda, Y.
Mwangi, D.M.
Tonukari, N.J.
Yamage, M.
Glew, E.J.
Villiers, Etienne P. de
 
Subject animal diseases
disease control
 
Description East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.
 
Date 2006-02-28
2010-05-07T11:05:01Z
2010-05-07T11:05:01Z
 
Type Journal Article
 
Identifier Graham S., et al. 2006. Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 103(9):3286-3291.
0027-8424
https://hdl.handle.net/10568/1406
https://doi.org/10.1073/pnas.0511273103
 
Language en
 
Rights Limited Access
 
Format p. 3286-3291
 
Publisher Proceedings of the National Academy of Sciences
 
Source Proceedings of the National Academy of Sciences of the United States of America