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The genetic basis of trypanotolerance in mice and cattle

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Title The genetic basis of trypanotolerance in mice and cattle
 
Creator Kemp, Stephen J.
Teale, A.J.
 
Subject DISEASE CONTROL
TRYPANOSOMIASIS
 
Description Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss that are characteristic of infection in susceptible hosts. As discussed here by Stephen Kemp and Alan Teale, the genetic control of this phenomenon might finally be yielding to gene mapping studies. Genetic regions determining susceptibility to trypanosomiasis in mice have been identified and parallel studies are well advanced in cattle. There is growing evidence that only modest numbers of genes are involved in determining the difference between a susceptible and a resistant animal. These observations raise a new series of important questions concerning the possible exploitation of major trypanotolerance genes and the way that they might function in different genetic and physical environments.
 
Date 2010-05-18T21:01:46Z
2010-05-18T21:01:46Z
1998-11-01
 
Type Journal Article
 
Identifier Kemp, S.J.; Teale, A.J. 1998. The genetic basis of trypanotolerance in mice and cattle. Review. Parasitology Today 14(11):450-454.
https://hdl.handle.net/10568/1566
 
Language en
 
Source Parasitology Today