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Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

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Title Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background
 
Creator Noyes, H.A.
Agaba, Morris
Anderson, S.
Archibald, A.L.
Brass, A.
Gibson, John P.
Hall, L.
Hulme, H.
Oh, S.J.
Kemp, Stephen J.
 
Subject GENETICS
MICE
 
Description Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitive to genetic background.
 
Date 2010-08-23T15:08:51Z
2010-08-23T15:08:51Z
2010-06-07
 
Type Journal Article
 
Identifier Noyes, H.A.; Agaba, M.; Anderson, S.; Archibald, A.L.; Brass, A.; Gibson, J.; Hall, L.; Hulme, H.; Oh, S.J.; Kemp, S. 2010. Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background. BMC Genomics 11:361.
https://hdl.handle.net/10568/2324
 
Language en
 
Source BMC Genomics