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Protective and inappropriate antibody responses in trypanosome-infected cattle

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Title Protective and inappropriate antibody responses in trypanosome-infected cattle
 
Creator Williams, D.J.L.
Taylor, K.
Newson, J.
Naessens, Jan
Authié, E.
 
Subject TRYPANOSOMES (PHYTOMONAS)
INFECTION
IMMUNE RESPONSE
DISEASE CONTROL
ANIMAL DISEASES
GLOSSINIDAE
GLOSSINA MORSITANS
NDAMA CATTLE
GOATS
TRYPANOSOMA CONGOLENSE
 
Description The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a particular VSG mediate the destruction and clearance to trypanosomes expressing that variant. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules, which in turn provoke specific antibody responses. Trypanosome infections are therefore characterized by waves of parasitaemia followed by waves of VSG-specific antibody. It is known that trypanotolerant N'Dama cattle infected with Trypanosoma congolense have significantly lower levels of parasitaemia than the more susceptible Boran cattle. It has been suggested that this reflects a more effective VSG-specific antibody response in the N'Damas. We have tested this hypothesis by examining VSG-specific antibody responses in N'Dama and Boran cattle during experimental infection with T. congolense.
 
Date 2010-12-09T11:11:59Z
2010-12-09T11:11:59Z
1995
 
Type Conference Paper
 
Identifier ISBN 92-9055-299-9
https://hdl.handle.net/10568/2824
 
Language en
 
Publisher ILRAD