Record Details

Bovine T-cell responses to defined Trypanosoma congolense antigens during infection

CGSpace Test

View Archive Info
 
 
Field Value
 
Title Bovine T-cell responses to defined Trypanosoma congolense antigens during infection
 
Creator Lutje, V.
Authié, E.
Boulange, A.F.
Williams, D.J.L.
 
Subject TRYPANOSOMA CONGOLENSE
INFECTION
ANIMAL DISEASES
IMMUNE RESPONSE
DISEASE CONTROL
GLOSSINIDAE
NDAMA CATTLE
 
Description Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (Bos taurus) cattle exhibit higher levels of IgG1 to CP than susceptible Borans. Boran cattle, on the other hand, have high levels of IgM to irrelevant antigens. During rechallenge infections, N'Dama cattle have higher levels of IgG1 to hsp70 while Boran cattle exhibit high titres of IgM to this antigen. Although Boran cattle do generate high titres of IgM to hsp70, N'Dama cattle develop higher levels of specific IgG antibody (Authie et al., 1993b). These observations are consistent with a possible dysfunction in isotype switch from IgM to IgG in Boran cattle. Because of the central role of T helper cells in induction of Ig isotype switch, the difference in antibody responses between N'Dama and Boran cattle migh reflect defective T helper cell function in the susceptible breeds during infection. We undertook a study to analyse T-cell function in cattle during infection with T. congolense. T-cell proliferative responses to a recombinant form of the hsp70 (R63), cysteine protease and VSG were measured in a group of Boran cattle following primary challenge with T. congolense. The role of CD4+ and CD8+ cells in the response was also investigated.
 
Date 2010-12-09T11:12:00Z
2010-12-09T11:12:00Z
1995
 
Type Conference Paper
 
Identifier ISBN 92-9055-299-9
https://hdl.handle.net/10568/2826
 
Language en
 
Publisher ILRAD