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Fluorescence quenching and measurement of captopril in pharmaceuticals

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Title Statement Fluorescence quenching and measurement of captopril in pharmaceuticals
 
Added Entry - Uncontrolled Name Chen, Yahong
Chang, Weixiao
Zhu, Xue
Wang, Ruiyong
Tian, Fengshou
 
Uncontrolled Index Term Captopril;, Enzyme-catalyzed product; Fluorescence quenching
 
Summary, etc. The mechanism of fluorescence quenching of the product S in the presence of captopril was studied. The maximum emission wavelength of the product S was at 405 nm with the excitation wavelength at 316 nm. It was found that the fluorescence quenching of product S was of a static one and the binding constant (K) was 9.29 × 106 J mol<span><sup>-1</sup></span>. A linear relationship was found between the relative fluorescence intensity of the product S-captopril system and the concentration of captopril. Under optimum conditions, the linear range of the calibration curve for captopril was 2~160 μg L<span><sup>-1</sup></span> with a correlation coefficient of 0.9926 and a detection limit of 0.1 μg L<sup>-1</sup>. The relative standard deviation (RSD) was 3.60%. The analytical results of the pharmaceuticals obtained by this novel method agreed quite well with those obtained by the KIO3 titrimetry.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2020-06-14 01:01:20
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/36487
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 57, ##issue.no## 3 (2020): IJBB Vol.57(3) [June 2020]
 
Language Note en