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Synergistic antiviral effects against SARS-CoV-2 by plant-based molecules

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Title Synergistic antiviral effects against SARS-CoV-2 by plant-based molecules
 
Creator Prasad, Ashish
Muthamilarasan, Mehanathan
Prasad, Manoj
 
Subject SARS-CoV-2
Plant-based drugs
Antiviral biomolecules
Plant-based vaccines
Traditional medicine
Synergistic effect
covid19
 
Description Accepted date: 12 June 2020
The exponential spread of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emphasizes the immediate
need for efective antiviral drugs and vaccines that could control and prevent the spread of this pandemic. Several new and
repurposed drugs are being tested for their efectiveness in the treatment regime, and the development of vaccines is underway. The availability of genome sequence information of the virus and the identifcation of potential targets to neutralize
and eradicate the infection have enabled the search for novel as well as existing molecules to perform the desired function.
However, the application of plants in the development of potential biomolecules, such as antibiotics and vaccines, is limited.
Traditional medicines involving plant-based formulations have proven successful in boosting immunity and providing tolerance to virus infections. Still, in-depth studies are not available to explore the bioactive compounds of plant origin and their
mechanism of action. Given this, the current opinion article conveys our thoughts and perspectives on the promising usage
of plant-based biomolecules in circumventing SARS-CoV-2, and how these molecules can work synergistically with other
potential drugs for treating SARS-CoV-2.
Authors’ work in this area is supported by
J.C. Bose National Fellowship Grant of Department of Science and
Technology, Government of India (File no.: JCB/2018/000001). A.P.
acknowledges the Council for Scientifc and Industrial Research, Govt.
of India for research fellowship. Authors are thankful to DBT-eLibrary
Consortium (DeLCON) for providing access to e-resources.
 
Date 2020-06-22T09:34:25Z
2020-06-22T09:34:25Z
2020
 
Type Article
 
Identifier Plant Cell Reports, 39(9): 1109-1114
1432-203X
https://doi.org/10.1007/s00299-020-02560-w
https://link.springer.com/article/10.1007/s00299-020-02560-w
http://223.31.159.10:8080/jspui/handle/123456789/1069
 
Language en_US
 
Format application/pdf
 
Publisher Springer Nature Publishing AG