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Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica

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Relation http://eprints.cmfri.org.in/13605/
https://link.springer.com/article/10.1007/s00044-019-02322-8
https://doi.org/10.1007/s00044-019-02322-8
 
Title Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica
 
Creator Antony, Tima
Chakraborty, Kajal
 
Subject Bioactive compounds
Biochemistry
Seaweed
 
Description Two previously unreported xenicane class of novaxenicin-type xenicin diterpenoids (1–2) bearing cyclonona[d]furo [2,3-b]pyrandiol and three xeniolide-type diterpenoids with unprecedented octahydrocyclonona[c]pyran-3(1H)-one backbones (3–5) were separated from the organic extract of the intertidal seaweed Padina tetrastomatica (family Dictyotaceae), collected from southern India. The compounds were deduced to bear a xenicane moiety with a 2-oxabicyclo[7.4.0]tridecane cyclic system. The structures of these specialized metabolites were attributed based on the extensive nuclear magnetic resonance spectral analyses, and comparison of related compounds. Xeniolide-type diterpenes (3–5) registered significantly greater attenuation potential against pro-inflammatory 5-lipoxygenase (IC50 ~ 2.04 mM) than that exhibited by non-steroidal anti-inflammatory drug ibuprofen (IC50 4.50 mM, P
 
Date 2019
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13605/1/Medicinal%20Chemistry%20Research_2019_Kajal%20Chakraborty_Xenicanes%20attenuate%20pro-inflammatory%205-lipoxygenase.pdf
Antony, Tima and Chakraborty, Kajal (2019) Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica. Medicinal Chemistry Research, 28 (4). pp. 591-607.