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An unreported bis-abeo cembrane-type diterpenoid with antioxidative and antilipoxygenase activities from the muricid gastropod mollusc Chicoreus ramosus

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Relation http://eprints.cmfri.org.in/14289/
https://pubmed.ncbi.nlm.nih.gov/30580610/
10.1080/14786419.2018.1527833
 
Title An unreported bis-abeo cembrane-type
diterpenoid with antioxidative and antilipoxygenase
activities from the muricid gastropod
mollusc Chicoreus ramosus
 
Creator Chakraborty, Kajal
Salas, Soumya
Joy, Minju
 
Subject Bioprospecting
Bioactive compounds
Biochemistry
Gastropods
 
Description The chemical analyses of ethyl acetate-methanol (EtOAc-MeOH) extract of muricid gastropod mollusk, Chicoreus ramosus from the southeastern coast of Indian peninsular led to the identification of unprecedented cembrane-type diterpenoid, which was characterized as (3E, 6E, 10E)-8a-butoxy-17(15→14), 20(12→11)-bis-abeo-cembra-3,6,10,14(17),15-pentaene (1). The structure of the studied cembrane was unambiguously assigned through the extensive spectroscopic experimentations. The antioxidant potentials of the bis-abeo cembrane as determined by in vitro 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid diammonium salt radical quenching potentials were greater (IC50 < 0.40 mg/mL) related to α-tocopherol (IC50 > 0.60 mg/mL). The pro-inflammatory anti-5-lipoxygenase potential of studied cembrane was higher (IC50 < 0.80 mg/mL) related to those demonstrated by ibuprofen and sodium salicylate (IC50 > 0.90 mg/mL).
 
Publisher Taylor and Francis
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14289/1/Natural%20Product%20Research_2020_Kajal%20Chakraborty_An%20unreported%20bis%20abeo%20cembrane%20type%20diterpenoid%20with%20antioxidative%20and%20anti%20lipoxygenase%20activities%20from%20the%20muricid%20gastropod%20mollusc%20Chicoreus.pdf
Chakraborty, Kajal and Salas, Soumya and Joy, Minju (2020) An unreported bis-abeo cembrane-type diterpenoid with antioxidative and antilipoxygenase activities from the muricid gastropod mollusc Chicoreus ramosus. Natural Product Research, 34 (12). pp. 1678-1686. ISSN 1478-6427 (Online)